慢性肝病患者空腹及餐后血清总胆汁酸测定

Measurement of serum total bile acid before and after meal in patinets with chronic liver diseases

目的 :检测慢性肝病患者空腹及餐后 2小时血清总胆汁酸 (TSBA)水平。方法 :分别测定乙型肝炎后肝硬化患者 30例 ,慢性乙型肝炎患者 30例及正常对照 35例的 TSBA;肝硬化组同时测定血清总胆红素(T.Bil)、白蛋白 (A)、丙氨酸转氨酶 (ALT)、天门冬氨酸氨酶 (AST)。结果 :肝硬化组及慢肝组空腹及餐后TSBA均明显高于对照组 (分别 P〈0 .0 1和 P〈0 .0 5)。对照组餐前、餐后 TSBA差别不显著 (P〉0 .0 5 )。肝硬化者 TSBA水平与 T.Bil、ALT、AST正相关 (rs=1.180 4 ;rs=0 .70 95;rs=0 .7782 ,三项均 P〈0 .0 0 5) ,与 A水平负相关 (rs=- 0 .40 18,P<0 .0 0 5)。结论 :肝损害是 TSBA升高的主要原因 ,检测空腹及餐后 2小时 TSBA对助诊慢性肝病 ,动态观察肝功变化有较大参考价值。

Objective:To measure serum levels of total bile acid (TSBA) before and two hours after meal in patients with chronic hepatitis B and liver cirrhosis Methods:TSBA in patients with chronic hepatitis B (n=30) and liver cirrhosis (n=30),and in control subjects (n=35),and serum T Bil A ALT AST in liver cirrhosis were measured Results:The study showed that TSBA before and affer meal were significantly higher in liver cirrhosis and chronic hepatitis compared with normal controls (p<0 01 and p<0 005 respectively) A degree of relationship was found between TSBA and laboratory biochemical test:T Bil (rs=1 1804,P<0 005),ALT(rs=0 7095,P<0 005),AST(rs=0 7782,P<0 005),A(rs=-0 4018,P<0 005) Conclusion:Impaired hepatocellular funciton is a major reason of the rise in TSBA levels in hepatopathy TSBA measurment can be useful in the evaluation and follow-up of chronic liver disease