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肠促胰岛素的功能研究进展 被引量：1

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摘要 研究表明，大约e／3的饮食所引起的胰岛素分泌都与肠道内分泌激素有关。其中，胃肠道分泌的肠促胰岛素是最主要的激素之一，其主要包括葡萄糖依赖性促胰岛素多肽（GIP）及胰高糖素样肽-1（GLP-1）。
作者 刘卉芳（综述） 陈凤玲（审校）
机构地区 上海交通大学医学院附属第三人民医院内分泌科
出处 《医学临床研究》 CAS 2010年第12期2351-2354,共4页 Journal of Clinical Research
关键词 胰岛素/分泌 胰高血糖素 综述文献
分类号 R587.1 [医药卫生—内分泌]
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参考文献25

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  • 2Herbach N,Goeke B,Schneider M,et al.Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development[J].Regul Pept,2005(1-3),125:103-117.
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同被引文献30

  • 1Buchwald H,Estok R,Fahrbach K,et al.Weight and type 2 diabetes after bariatric surgery:systematic review and meta-analysis[J].Am J Med,2009,122(3):248-256.
  • 2Abbatini F,Rizzello M,Casella G,et al.Long-term effects of laparoscopic sleeve gastrectomy,gastric bypass,and adjustable gastric banding on type 2 diabetes[J].Surg Endosc,2010,24(5):1005-1010.
  • 3Wong SK,Kong AP,Mui WL,et al.Laparoscopic bariatric surgery:a five-year review[J].Hong Kong Med J,2009,15(2):100-109.
  • 4Schauer PR,Kashyap SR,Wolski K,et al.Bariatric surgery versus intensive medical therapy in obese patients with diabetes[J].N Engl J Med,2012,366(17):1567-1576.
  • 5Mingrone G,Panunzi S,De Gaetano A,et al.Bariatric surgery versus conventional medical therapy for type 2 diabetes[J].N Engl J Med,2012,366(17):1577-1585.
  • 6Elrick H,Stimmler L,Hlad CJ Jr,et al.Plasma Insulin Response To Oral And Intravenous Glucose Administration[J].J Clin Endocrinol Metab,1964,24:1076-1082.
  • 7Donath MY,Burcelin R.GLP-1 effects on islets:hormonal,neuronal,or paracrine?[J].Diabetes Care,2013,36 Suppl 2:S145-148.
  • 8Broide E,Bloch O,Ben-Yehudah G,et al.GLP-1 receptor is expressed in human stomach mucosa:analysis of its cellular association and distribution within gastric glands[J].J Histochem Cytochem,2013,61(9):649-658.
  • 9Sandoval D.CNS GLP-1 regulation of peripheral glucose homeostasis[J].Physiol Behav,2008,94(5):670-674.
  • 10Kappe C,Tracy LM,Patrone C,et al.GLP-1 secretion by microglial cells and decreased CNS expression in obesity[J].J Neuroinflammation,2012,9:276.

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医学临床研究
2010年 第12期

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