医用臭氧与玻璃酸钠治疗膝骨性关节炎疗效对比分析

Efficacy comparison of medical ozone with sodium hyaluronate in the treatment of knee osteoarthritis

目的 观察医用臭氧治疗膝骨性关节炎的临床疗效.方法 选择65例膝骨性关节炎患者,随机分为 A组（医用臭氧组）和 B组（玻璃酸钠组）,其中A组关节腔内注射40ml的医用臭氧,33例;B组关节腔内注射玻璃酸钠25mg/周,5周为1疗程,32例,比较两组病例治疗前及治疗后1个月、6个月、1年的VAS和总有效率.结果 两组患者治疗后视觉模拟评分与治疗前相比明显降低（P〈0.01）,在治疗后第1个月A组与B组差异无统计学意义,治疗后6个月、1年A组与B组差异均有统计学意义（P〈0.05和P〈0.01）.两组患者治疗后1年膝关节功能的总有效率比较差异有统计学意义（P〈0.05）,全部患者未见明显的不良反应和副作用.结论 医用臭氧治疗膝骨性关节炎能有效解除关节疼痛,临床疗效满意,并且操作简便、成本低、见效快、无明显副作用,是一种治疗膝骨性关节炎的好方法.

Objective To examine the efficacy of medical ozone （O3） in the treatment of knee osteoarthritis （ OA ）. Methods A total of 65 OA patients were randomly divided into O3 group （group A） and sodium hyaluronate group （group B） ,with 33 patients in the group A and 32 in the group B. The patients in the group A were treated with 40 mL O3 by intraeavitary injection. And those in the group B were given intracavitary injection of sodium hyaluronate 25 mg once a week for five consecutive weeks. The visual analogue scale （VAS） score and the total effective rate were compared between the two groups before and 1 month, 6 months and 1 year after the treatment, respectively. Results The VAS score was significantly decreased in both groups after the treatment when compared with that before the treatment. And it was greatly lower in the group A than that in the group B 6 months and 1 year after the treatment （ P 〈 0.05 and P 〈 0.01 ）. There existed significant difference in the total efficiency of knee function between the two groups 1 year after the treatment. No obvious side effects were observed in all the patients. Conclusion Intracavitary injection of 03 can effectively relieve the joint pain in patients with knee osteoarthritis, with satisfactory clinical efficacy,low cost and no obvious side effects.