肝病患者血清HA、PⅢNP、LN、Ⅳ-Col水平与临床分型的关系

Relationship Between Serum Levels of HA,PⅢNP,LN,Ⅳ-Col and Clinical Type in Hepatic Disease

目的初步评价肝病患者血清4项指标透明质酸(HA)、层黏蛋白(LN)、Ⅲ型前胶原N端肽(PⅢNP)、ⅣC型前胶原含量(Ⅳ-Col)与慢性化及临床分型的关系。方法对145例肝病患者采用化学发光法测定血清中HA、PCⅢ、LN、Ⅳ-Col水平,比较这4项指标与临床分型的相关性。结果血清HA、PⅢNP、LN、Ⅳ-Col水平含量随着病程的进展有逐步升高的趋势,即急性肝炎<慢肝轻度<慢肝中度<慢肝重度<肝硬化。结论血清中HA、PⅢNP、LN、Ⅳ-Col水平可反映肝病慢性化趋势,与临床一致,是判断早期肝硬化的相对灵敏和可靠指标。

Objective To preliminarily analyze the correlation between the serum levels of HA,LN,PⅢNP,Ⅳ-Col,and chronicity or clinical type in patients with viral hepatitis. Methods The serum levels of HA,PⅢNP,LN and Ⅳ-Col in 145 patients with hepatic disease were measured by radioimmunity method.The correlation between the serum levels of HA,LN,PⅢNP,Ⅳ-Col,and clinical type was compared and analyzed. Results The serum levels of HA,PCⅢ,LN,and Ⅳ-Col in patients with hepatic disease appeared a trend of increasing,which was the pattern： ＂acute hepatitis 〈mild chronic hepatitis 〈moderate chronic hepatitis〈 severe chronic 〈hepatitis hepatic cirrhosis＂. Conclusions The serum levels of HA,PⅢNP,LN and Ⅳ-Col could reflect the severity of hepatic fibrosis and inflammation,and might be the sensitive and reliable index for diagnosing hepatic cirrhosis in the early stage.