2009年江西省南昌市乙型病毒性肝炎疫苗补种活动预防接种异常反应分析

Analysis on adverse events following supplementary immunization activity of hepatitis B in Nanchang,Jiangxi province,2009

目的分析南昌市2009-2010年度乙型病毒性肝炎（乙肝）疫苗（HepB）国家重大专项补种活动的预防接种异常反应（AEFI）发生特征,探讨HepB补种活动的安全性及减少预防接种异常反应的措施。方法采用描述性方法对相关指标进行流行病学分析。结果南昌市2009-2010年8-15岁儿童HepB补种活动共报告AEFI 23例,发生率为1.72/10万剂次,其中一般反应12例,异常反应10例;临床损害以过敏性反应多见;接种后〈24 h出现异常反应的占69.57%;绝大多数病例预后良好。结论接种HepB后的预防接种异常反应发生率低。儿童在接种HepB后24 h是监测的重点,应加强监测,提高预防接种异常反应的预防和处理水平。

Objective To analyze the characteristics of adverse event following supplementary immunization activity（SIA） of Hepatitis B in Nanchang during 2009-2010,understand the safety of Hepatitis B vaccine and explore measures to reduce the adverse event.Methods The descriptive epidemiology analysis was conducted on related indexes.Results Twenty three adverse events were reported among the children aged 8-15 years in SIA during this period,the incidence rate was 1.72/lakh dose.Among these events,12 were mild reactions,10 were serious reactions and most of them were allergic reactions.Up to 69.57% of the adverse events occurred within 24 hours after immunization.Most cases were cured.Conclusion The incidence of adverse event following SIA of hepatitis B was low in Nanchang.It is necessary to strengthen the surveillance of adverse event following the vaccination among the vaccinated children and improve the prevention and response of adverse event following immunization.