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吲哚美辛对脑梗死急性期炎症反应的影响 被引量:1

Effect indomethacin on acute inflammatory response in patients with acute cerebral infarction
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摘要 目的研究吲哚美辛对急性脑梗死(ACI)患者血清C反应蛋白(CRP)及可溶性细胞间粘附分子-1(sICAM-1)水平的影响,探讨吲哚美辛对脑梗死急性期炎症反应的影响。方法将60例ACI患者随机分为吲哚美辛治疗组和常规治疗组,并选取正常体检者30人组成对照组。在治疗前及治疗第7天、第14天检测血清CRP和sICAM-1含量,并进行神经功能缺损程度评分(NIHSS)评定。结果两组治疗前血清sICAM-1、CRP含量较对照组显著升高(P<0.01),治疗后较治疗前显著下降(P<0.01),且吲哚美辛治疗组较常规治疗组下降显著(P<0.05);两组治疗14d时NIHSS较治疗前显著下降(均P<0.01),且吲哚美辛治疗组较常规治疗组下降明显(P<0.05);吲哚美辛治疗组未出现明显副反应,耐受性良好。结论吲哚美辛能明显降低ACI患者血清CRP及sICAM-1水平;有助于ACI患者的神经功能恢复并且安全性较好。 Objective To study the effect of indomethacin on the level of serum C-reactive protein and soluble intercellular adhesion molecule-1(Siam-1) and inflammatory response in patients with acute cerebral infarction(ACI).Methods 60 patients with ACI were randomly divided into the indomethacin therapy group and the conventional therapy group.Thirty healthy people were selected simultaneously as controls.On 7d and 14d before and after treatment,serum CPR,Siam-1 levels and the scores of neurological deficit(NDS) were evaluated.Results Before treatment,serum sICAM-1 and CRP levels of treatment groups was significantly higher than the control group(P 〈0.01),while after treatment,decreased(P〈0.01).Indomethacin treatment group compared with conventional treatment group,serum sICAM-1 and CRP levels decreased significantly(P〈0.05).In two groups,NIHSS of 14d was significantly decreased than before treatment(P〈0.01),and compared with conventional treatment group,that of indomethacin treatment group decreased significantly(P〈0.05).Indomethacin treatment group showed no significant side effects and good tolerability.Conclusion Indomethacin significantly decreased the serum CRP in patients with ACI and sICAM-1 level,and may help to restore neurological function in patients with ACI and shows good safety.
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2010年第12期1079-1081,共3页 Journal of Apoplexy and Nervous Diseases
基金 黑龙江省卫生厅科研课题(项目编号:2007-417)
关键词 吲哚美辛 脑梗死 C反应蛋白 可溶性细胞间粘附分子-1 Indomethacin Cerebral infarction C-reactive protein Soluble Intercellular Adhesion Molecule-1
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参考文献9

  • 1Danton GH, Dietrich WD. Inflammatory mechanisms after ischemia and stork [ J ]. J Neuropathol Exp Neuro1,2003,62 ( 2 ) : 127-136.
  • 2Gearing AJ, Newman W. Circulating adhesion molecules in disease [J]. Immunol Today, 1993,14(10) :506-512.
  • 3Konemoto Y, Nakase H, Akita N, et al. Effects of anti-intercellular adhesion molecule-1 antibody on reperfusion injury included by late reperfusion in the rat middle cerebral artery occlusion model[J]. Neurosurgery, 2002,51 ( 4 ) : 1034 - 1041.
  • 4Dziedzic T,Gryz EA,Turaj W,et al. Serum interleukin45 soluble receptor in relation to interleukin-6 in stroke patients [ J ]. J Mol Neurosci,2004,24(2) :293-298.
  • 5Silvestri A, Vitale C, Ferretti F, et al. Plasma levels of inflammatory C- reactive protein and interleukin-6 predict outcome in elderly patients with stroke [ J ]. J Am Geriatr Soc,2004,52 ( 9 ) : 1586-1587.
  • 6王爱民,周颖,肖波,张智博.脑梗死患者血清高敏C反应蛋白水平的变化及其临床意义[J].临床神经病学杂志,2005,18(2):153-154. 被引量:132
  • 7Studahl M,Rosengren L, Gumther G, et al. Difference in pathogenesis between herpes simplex virus type 1 encephalitis and tick-home encephalitis demonstrated by means of cerebrospinal fluid markers of glial and neuronal destruction [ J ]. J Neurol,2000,247 ( 8 ) :636 -642.
  • 8Vries J, Thijssen WA, Snets 5E, et al. Intraoperative values of 5100 protein,myelin basic: protein, lactate and albumin in the CSF and serum of neurosurgical patients [ J ]. J Neurol Neurosurg Psychiatry, 2001,71 (5) :671-674.
  • 9谭占国,柴宗举,冯祖荫.消炎痛对兔脑外伤后脑组织氧自由基反应的影响[J].郑州大学学报(医学版),2001,36(1):48-50. 被引量:7

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同被引文献8

  • 1夏强,钱令波.心脑缺血再灌注损伤的机制及防治策略研究进展[J].浙江大学学报(医学版),2010,39(6):551-558. 被引量:47
  • 2Huang J, Upadhyay UM, Tamargo RJ. Inflammation in stroke and focal cerebral isehemia [J]. Surg Neuro1,2006 ;66 ( 3 ) : 232-45.
  • 3Vila N, Castillo J, Davalos A,et al. Pminflammatory cytokines and early neurological worsening in ischemic stroke ( J ). Stroke, 2000; 31 ( 10 ) : 2325.
  • 4Di Nopoli M, Di Gianfilippa G, Sollecito A, et al. C-reactive protein andoutcome after first ischemic stroke [J]. Stroke,2000 ;31 ( 1 ) : 238-9.
  • 5Sepulveda JL, Mehta JL. C-reactive protein and cardiovascular disease : a critical appraisal[J]. Curr Opin Cardia1,2005 ;20 (5) :408-16.
  • 6Mueller C, Buettner H, Hodgon JM, et al. Inflammation and a long term mortality after non-ST elevation acute coronary syndrome treated with a very invasive strategy in 1042 consecutive patients [J]. Circulation, 2002 ; 105 : 1412.
  • 7Peps MB, Hirschfield GM. C-reactive protein: a critical up-date [ J]. ClinInvest ,2003 ; 111 ( 12 ): 1805-12.
  • 8Hartl R, Schurer L, Schmid-schonbein GW,et al. Experimental antileuko- cyte interventions in cerebral ischemia [J].Cere Blood Flow Metab, 1996;16(6) :1108-10.

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