帕金森病认知障碍研究

The impaired cognitive function in Parkinson's disease with dementia

目的研究帕金森病痴呆患者的认知障碍特点。方法采用语义流畅性、语音流畅性、动作流畅性测验与物品和动作命名测验,评定30例PD无痴呆患者、30例PDD患者与60名正常老年人。结果与正常对照组比较,PD无痴呆患者存在动作流畅性损害(P<0.01),PDD患者3项言语流畅性与物品和动作命名均受损(P<0.01)。结论 PDD患者存在执行功能障碍与命名损害,PDD是一种伴有皮质功能损害的、以额叶皮质下功能障碍为主要特点的认知损害性疾病。

Objective To study the characterization of cognitive function in Parkinson＇s disease with dementia.Method Cognitive function was examined in Parkinson＇s Disease（PD） patients（n=30）,Parkinson＇s disease with dementia（PDD） patients（n=30） and healthy elderly control subjects（n=60）.Neuropsychological evaluation contained semantic,phonemic fluency test,action fluency test,objective and naming test.Results The verbal fluency tests and naming tests were impaired in PDD patients compared with the healthy elderly control group（P〈0.01） while action fluency test was impaired in PD patients compared with the healthy elderly control group（P〈0.01）.Conclusion Executive function deficit and naming impairment are found in PDD patients.It shows that PDD is characterized by the addition of cortical dysfunction upon a predominant and progressive fronto-subcortical impairment.