早发型重度子痫前期母婴结局38例分析

Clinical analysis of maternal and neonatal outcomes of 38 cases with early onset severe preeclampsia

目的 探讨早发型重度子痫前期对母婴结局的影响. 方法 分析早发型重度子痫38例（早发组）与同期晚发型重度子痫112例（晚发组）的围产期情况和分娩172例婴儿的结局. 结果 两组孕产妇并发症比较：早发组发生率36.8%,晚发组16.1%,差异有统计学意义（P＜0.01）;围生儿比较：早发组围生儿体质量明显低于晚发组（P＜0.01）,早发组发生新生儿窒息、围生儿病死率、FGR明显高于晚发组（均P＜0.05）. 结论 早发型重度子痫孕妇并发症发生率高,围生儿病情严重、预后不良.早发型重度子痫孕妇应严格选择病例行短期的期待疗法.

Objective To evaluate the maternal and infant outcomes in the pregnancies of severe early-onset preeclampsia. Methods We retrospectively studied the pregnancy outcomes in 38cases with severe early-onset preeclampsia and 112 cases with later-onset preeclampsia and their 172 neonates in Huainan maternal and child care service centre during Jan 2009 to Mar.2010. Results As for the mothers＇ complications such as preeclampsia,cardiac insufficiency,HELLP syndrom,liver function abnormality,kidney function failure,placental abruption,mass ascites,and infant death in uterus,in early-onset group the incidence rate was 36.8%,significantly higher than that in the late-onset group 16.1%（P〈0.01）.the perinatal outcome：birth weight in the early-onset group was 1950 ±603.1,significantly less than the late-onset group 2854 ± 672.9（P〈0.01）;neonates asphyxia incidence rate in the earlyonset group was 17.4%,significantly higher than the late-onset group 3.1%（P〈0.01）,infant death incidence rate in the early-onset group was 15.2%,significantly higher than the late-onset group 1.6%（P〈0.01）,and FGR incidence rate in the early-onset group was 23.9%,significantly higher than the late-onset group 11.1%（P〈0.05）. Conclusion the early-onset preeclampsia is strongly associated with a number of pregnancy complications and perinatal conditions.