基于闪光视觉诱发电位的颅内压无创检测及其仪器实现

Instrument realization of non-invasive intracranial pressure measurement based on flash visual evoked potential

闪光视觉诱发电位能应用于颅内压无创检测的原理基础是其N2波潜伏期的变化与颅内压值成正相关关系。研究发现,用乘幂关系表示颅内高压段两者之间的相关关系,能更准确地反映高颅压段的变化情况。在此基础上,利用虚拟仪器技术、微弱信号提取技术和生物医学技术研制成功基于闪光视觉诱发电位的颅内压无创检测分析仪,在第三军医大学附属西南医院和新桥医院的临床试验显示有创颅内压值和无创颅内压值的相关性系数分别为西南医院r=0.9593,新桥医院r=0.9751,均大于0.9,表明该仪器可以有效替代有创颅内压监测,无创颅内压值与有创颅内压值的相对误差控制在允许范围内,可以满足临床应用要求。

The principle basis of that flash visual evoked potential（FVEP） can be used to measure intracranial pressure（ICP） non-invasively is the positive correlation between the latency of N2 wave in FVEP signal and ICP.Currently,the correlation relation is generally believed to be linear;however,there will be comparatively large error in high intracranial pressure segment.Further study shows that the correlation relation in high pressure segment could be expressed as a power relation,which can reflect the change of ICP more accurately.Based on this knowledge,virtual instrument technology,weak signal extraction technology and biomedical technology are applied to research and develop a non-invasive ICP measurement instrument successfully.Clinical applications show that the instrument can be an effective substitute for invasive ICP measurement instrument and can reflect the change trend of ICP correctly.The correlation coefficients r are 0.959 3 in Xinan Hospital and 0.975 1 in Xinqiao Hospital;both are larger than 0.9.The relative error between non-invasive ICP and invasive ICP values can be controlled in a permitted range,which means that the instrument can satisfy the requirement of clinical applications well.