摘要
目的探讨无肌松药条件下舒芬太尼复合七氟醚麻醉诱导的适宜剂量。方法择期全麻下行腹腔镜卵巢囊肿剥除术患者120例,根据七氟醚麻醉诱导时舒芬太尼用量不同(0.2、0.3、0.4、0.5μg/kg)随机分为四组(S1~S4组),每组30例。记录患者入室后10min(T0)、插管前即刻(T1)、插管后即刻(T2)、插管后1min(T3)、3min(T4)、5min(T5)、10min(T6)、术毕(T7)和拔管前1min(T8)的MAP和HR,并对各组的插管条件进行评分。结果四组插管评分S4组>S3组>S2组>S1组(P<0.05)。与T0时比较,T1时四组MAP下降、HR减慢(P<0.05),T2、T8时S1组MAP升高(P<0.05)。与S1组比较,T4~T6、T8时S2、S3、S4组MAP下降;与S2组比较,T2~T6时S3、S4组MAP下降(P<0.05)。S4组麻黄碱及阿托品用量多于S3组(P<0.05)。结论无肌松条件下,舒芬太尼0.4μg/kg复合七氟醚用于妇科手术麻醉诱导,能提供较好的插管条件和稳定的血流动力学。
Objective To explore the optimal dose of sufentanil combined with sevoflurane in the absence of muscle relaxant during general anesthesia induction.Methods A total of 120 patients undergoing elective laparoscopic oophorocystectomy were randomly divided into 4 groups with 30 cases each. The anesthesia was induced with sevoflurane and 0.2,0.3,0.4,0.5 μg/kg sufentanil(S1,S2,S3,S4 group). Mean arterial pressure (MAP) and heart rate (HR) were measured at baseline (T0),before intubation (T1),1,3,5,10 min after intubation (T2-6),at the end of surgery (T7),and 1 min before extubation (T8). Intubation scores were also recorded. Results The intubation scores were as the following sequence:S4 S3 S2 S1 (P0.05). Compared with T0,MAP and HR decreased in each group at T1 while increased at T2,8 in group S1(P 0.05). Compared with group S1,MAP was lower at T4-6,8 in groups S2-4 (P 0.05). Compared with group S2,MAP was lower at T2-6 in groups S3,4 (P 0.05). The consumption of ephedrine and atropine was more in group S4 than group S3 (P 0.05). Conclusion Sufentanil 0.4 μg/kg combined with sevoflurane without muscle relaxant can provide excellent intubating conditions and stable hemodynamics during anesthesia induction in patients undergoing gynecologic surgery.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2010年第12期1046-1048,共3页
Journal of Clinical Anesthesiology
关键词
七氟醚
舒芬太尼
麻醉诱导
剂量
Sevoflurane
Sufentanil
Induction of anesthesia
Dose