全麻和腰麻对大鼠脂肪栓塞死亡率的影响

Comparison of general anesthesia with spinal anesthesia for the mortality in rats with fat embolism

目的比较全麻和腰麻对大鼠脂肪栓塞死亡率的影响。方法大鼠375只,随机分为全麻组(GF组)、腰麻组(SF组)和无麻醉组(F组),每组125只。分别在全麻、腰麻或无麻醉20min后,经尾静脉注入大鼠半数致死量的脂肪。观察并记录注入脂肪后2、8、12、24h内三组大鼠的死亡情况。结果 GF组死亡率低于SF组和F组(P<0.05),SF组和F组比较差异无统计学意义。结论与腰麻比较,全麻可以明显降低大鼠脂肪栓塞的死亡率。

Objective To compare the influence of general anesthesia and spinal anesthesia on the mortality in rats with fat embolism.Methods Three hundred and seventy five rats were randomly assigned to receive general anesthesia （group GF,n=125）,spinal anesthesia （group SF,n=125）,or no anesthesia （group F,n=125）.Rats were injected with a half lethal dose of fat from caudal vein 20 min after anesthesia induction. The mortality was recorded at 2,8,12,and 24 h after fat injection,respectively.Results The mortality was lower in group GF than those in groups SF and F （P0.05）,while there was no statistical difference between group SF and group F.Conclusion The mortality in rats with fat embolism under general anesthesia was lower than that under spinal anesthesia.