药物毒理学研究进展

Advances in the research of drug toxicology

近年来,随着分子生物学、细胞生物学、系统生物学等前沿学科及相关技术,特别是基因组学、蛋白质组学和代谢组学的飞速发展,药物毒理学经历了研究思路从传统毒理学向发现毒理学转化,研究方法从整体实验向体外实验转化,研究深度从器官、组织水平向分子、基因水平转化,评估理念从单一毒性评价向多学科综合评价转化的发展过程。

In recent years,cutting-edge disciplines have been developed rapidly,such as molecular biology,cell biology and system biology,and related technologies have been also developed,especially those in genomics,proteomics and metabolomics.With the developments,drug toxicology has experienced the translation from traditional toxicology into discovery toxicology,from the whole experiments into in vitro methods,from organ,tissue levels into the molecular,genetic levels and from a single assessment of toxicity into multidisciplinary evaluation.