玉米中霉菌毒素对仔猪疫苗免疫应答的影响

Effects of Mycotoxin from Maize on Immune Response of Vaccine for Piglets

[目的]研究霉变玉米中的毒素对仔猪免疫应答的影响。[方法]使用ELISA方法测定了霉变玉米中黄曲霉毒素B1和赭曲霉毒素A的含量;将霉变玉米饲喂仔猪,并测定仔猪血清中相应的抗体效价。[结果]试验组抗体水平明显低于对照组,免疫器官的组织切片也表明霉菌毒素可以明显抑制仔猪的免疫应答反应。[结论]玉米霉菌毒素对仔猪内脏器官和免疫应答具有重要影响。

[Objective] The aim of this study was to investigate the effects of mycotoxin from moldy maize on immune response of piglets.[Method] ELISA method was used to determine the content of Aflatoxin B1 and ochratoxin A in maize;after the piglets were fed with the moldy maize,the corresponding antibody titers in the serums of piglets were measured.[Result] Antibody levels of tested group were obvious lower than that of the control,while the histological section of immune organs also suggested that mycotoxin could significantly inhibit the immune response of piglets.[Conclusion] Mycotoxin in maize had important effects on the internal organs and immune response of piglets.