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Romidepsin:治疗皮肤T细胞淋巴瘤的新药 被引量：1

Romidepsin:a new therapy for cutaneous T-cell lymphoma
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摘要 Romidepsin是一种新的组蛋白去乙酰化酶抑制剂,可引起组蛋白超乙酰化,使细胞周期停滞,造成某些肿瘤细胞株程序性凋亡。在美国该药已被批准用于治疗先前曾接受过至少1种系统治疗的皮肤T细胞淋巴瘤患者。本文从romidepsin的研发背景、药理学、临床研究以及安全性评价等方面进行系统的概述,以推动romidepsin的进一步应用和研究。 Romidepsin is a new histone deacetylase（HDAC） inhibitor which causes the accumulation of acetylated histones,and induces cell cycle arrest and apoptosis of some cancer cell lines.Romidepsin is recently approved for the treatment of cutaneous T-cell lymphoma（CTCL） patients who have received at least one prior systemic therapy in USA.This review outlines the background of the discovery,pharmacology, clinical studies and safety evaluation of romidepsin in order to make some contribution to further application and research of romidepsin.
作者 张静 刘俏 彭六保 易利丹 阳巧凤 曾小慧
机构地区 中南大学湘雅二医院药学部 中南大学药学院
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2011年第1期1-4,共4页 Chinese Journal of New Drugs and Clinical Remedies
关键词 ROMIDEPSIN 淋巴瘤 T细胞 皮肤 组蛋白去乙酰酶抑制剂 药理学 临床 romidepsin lymphoma T-cell cutaneous histone deacetylase inhibitor pharmacology clinical
分类号 R979.1 [医药卫生—药品]
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参考文献22

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同被引文献12

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中国新药与临床杂志
2011年 第1期

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