曲美布汀联合聚乙二醇4000治疗老年人便秘型肠易激综合征

Effects of trimebutine combined with macrogol 4000 powder on constipated irritable bowel syndrome in old patients

目的观察曲美布汀联合聚乙二醇4000治疗老年人便秘型肠易激综合征的疗效方法68例便秘型肠易激综合征老年患者,给予口服曲美布汀胶囊0.2 g,3次·d^(-1),聚乙二醇4000散利10 g,1次·d^(-1),疗程均为15 d。观察患者大便次数及腹痛、腹胀缓解程度。结果治疗后患者腹痛、腹胀及便秘等症状分级明显好转,与治疗前比较差异非常显著(均P<0.01),总有效率为93%。结论曲美布汀联合聚乙二醇4000治疗老年人便秘型肠易激综合征,疗效满意,不良反应少。

AIM To observe the effects of trimebutine combined with macrogol 4000 powder on constipated irritable bowel syndrome.METHODS Sixty-eight old patients with constipated irritable bowel syndrome were administered with orally trimebutine capsules 0.2 g,po,tid,and macrogol 4000 powder 10g, qd,for 15 days.The stool frequency,abdominal pain and abdominal distension were observed.RESULTS The total effective rate was 93%.The stool frequency,abdominal pain and abdominal distension were improved significantly after the treatment（P0.01）.CONCLUSION Trimebutine combined with macrogol 4000 powder is effective in constipated irritable bowel syndrome with less adverse drug reaction.