系统性硬化症血管内皮素-1和血管性血友病因子水平测定及意义

Endothelin-1 and Von Willebrand factor in plasma of patients with systemic sclerosis

目的研究血管内皮素-1(endothelium-1,ET-1)和血管性血友病因子(von willebrand factor,vWF)水平与系统性硬化症及与病情活动度的相关性,以探讨其在发病机制中的作用及指导治疗。方法以疾病活动期系统性硬化症和系统性红斑狼疮患者各30例为研究对象,并用健康人30例作为健康对照组,分别测定血浆ET-1及血清vWF浓度。结果系统性硬化症患者ET-1及vWF浓度明显高于系统性红斑狼疮患者(P<0.01),后者又明显高于健康对照组(P<0.01);部分患者病情稳定后ET-1及vWF浓度明显下降。结论 ET-1及vWF水平与系统性硬化症疾病活动性呈正相关,ET-1及vWF可能通过加重血管病变从而诱发疾病活动。

Objective： To study the connection of（endothelium-1,ET-1） and（von willebrand factor,vWF） in systemic sclerosis（SSc） and the connection with the activity to find out their effects on the mechanism of SSc and guide the treatment.Methods： The plasma ET-1 and vWF was detected in the patients of SSc and SLE and also the normal controls at the same time.Results： The ET-1 and vWF density of SSc were obviously higher than those of SLE,the latter was also obviously higher than that of the normal controls（P0.01）;The ET-1 and vWF density declined obviously when the patients condition were controlled（P0.01）.Conclusion： ET-1 and vWF are closely connected with activity of SSc,which may strengthen the vessel damage and lead to the activity.