胎儿胼胝体发育不良的超声和磁共振对比观察

Comparison of ultrasound and MRI in the prenatal diagnosis of agenesis of corpus callosum

目的探讨超声与MRI在胎儿胼胝体发育不良(ACC)产前诊断中的应用价值。方法超声怀疑胎儿ACC孕妇16名,均在超声检查后3天内接受胎儿MR检查。将超声、MRI结果与出生后或引产后结果对照。结果 16名孕妇共检出胎儿16胎,MRI证实14胎为胎儿ACC(出生后随访证实5胎,引产后证实9胎),1胎为单纯双侧脑室扩张伴灰质易位,1胎为脑白质、脑干发育不良。MRI与超声比较,诊断胎儿ACC一致者7胎;超声可疑、MRI肯定者7胎;对于其伴发中枢神经系统畸形,两者一致者7胎,MRI多于超声者4胎。结论超声检查是产前筛查胎儿ACC的普遍方法;MRI对胎儿ACC的显示明显优于超声,有助于明确诊断胎儿ACC并判断其分型及合并畸形。

Objective To observe the value of ultrasound（US） and MRI in the prenatal diagnosis of agenesis of corpus callosum（ACC）.Methods Fetal ACC was suspected in 16 pregnant women by prenatal US.Fetal MRI was performed within 3 days after prenatal US.The findings of prenatal US and fetal MRI were compared with the results of autopsy or following up imaging data after birth.Results Sixteen fetuses were detected in 16 pregnant women.Fourteen fetuses of ACC suspected with prenatal US were confirmed with MRI（5 confirmed with following-up after birth and 9 with autopsy）.Another 2 fetuses were not ACC,1 was ventriculomegaly companying with gray matter translocation and the other was cerebral white matter and brain stem hypoplasia.Of all the fetal ACC confirmed with MRI,US was consistent with MRI in 7 fetuses,and other 7 fetuses were suspected with US.For the other associated abnormalities in central nervous system,MRI was consistent with prenatal US in 7 fetuses.MRI demonstrated more associated abnormalities than US in 4 fetuses.Conclusion US is the optimal choice for detecting fetal anomalies.However,MRI is superior to US in the diagnosis of ACC and contributes to the definite diagnosis of ACC and possible associated abnormalities.