首发精神分裂症患者及其正常一级亲属血脂和肥胖的研究

Dyslipidemia and obesity in first-episode drug-naive patients with schizophrenia and their first-degree relatives

目的 研究在排除抗精神病药物影响下精神分裂症患者和其正常一级亲属的脂代谢以及肥胖情况.方法 选择58例符合中国精神障碍分类与诊断标准第三版（CCMD-3）和精神障碍诊断统计手册第四版（DSM-IV）中分裂症诊断标准的首发且未服药的精神分裂症患者（患者组）以及其22例正常一级亲属（亲属组）、24例普通人群（正常对照组）为研究对象,检测腰围、腰臀比、体重指数以及血脂水平（甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇）.结果 患者组的血脂异常发病率为20.7%,高于对照组的,且差异具有显著性（P＜0.05）;而且患者组高密度脂蛋白胆固醇水平（1.31±0.28）mmol/L明显低于对照组的（1.46±0.28）mmol/L,差异亦具有显著性（P＜0.05）,而其他血脂代谢各项指标与对照组相比,都没有显著性差异（P＞0.05）.另外,亲属组的各个指标与对照组相比,均无显著性差异.结论 与普通人群相比,精神分裂症患者具有较高的血脂异常发病率,精神分裂症与脂代谢异常之间存在一定的相关性.

Objective To study lipid metabolism and obesity in first--episode drug--naive schizo phrenia and their first-- degree relatives. Methods In this cross -- sectional study, waist circumference （WC）, waist--hip ratio （WHR）, body mass index （BMI）, and the levels of triglyceride （TG）, total cho- lesterol （ TC）, high density lipoprotein cholesterol （ HDL-- C）, low density lipoprotein cholesterol （LDL-- C） were measured in 58 first--episode drug--naive patients with schizophrenia, 22 of their first---degree rel atives, and 24 healthy comparison subjects. Results The mobidity of dystipidemia in patients with schizophrenia were 20.7 ~, which was significantly higher than that in healthy subjects （P 〈 0.01）. The level of HDL-C in patient group （1.31±0.28）mmol/L was significant difference from that in healthy subjects. There is no difference in TG, TC, LDL C level among the three groups. Conclusions Dyslipidemia is highly prevalent in first--episode patients with schizophrenia. The contri bution of dyslipidemia to the mechanism underlying schizophrenia needs to be further studied.