期刊文献+

染色体易位与恶性肿瘤 被引量:1

原文传递
导出
摘要 染色体易位是恶性肿瘤重要的分子遗传学改变之一,一方面,染色体易位可使原癌基因异常表达;另一方面,染色体易位使易位后相邻的基因融合,形成新的融合基因并表达相关产物, 可导致细胞生长和分化等生物学行为的改变,特异的易位或易位基因产物可作为肿瘤特征性标志,检测这些标志有助于肿瘤的诊断,亦可预测肿瘤患者的预后.
作者 景丽 郑杰
出处 《中华病理学杂志》 CAS CSCD 北大核心 2011年第2期138-140,共3页 Chinese Journal of Pathology
  • 相关文献

参考文献18

  • 1汪亚伦,王彤,许凤,冮岩,王杰.伴有6;9染色体易位急性髓系白血病患者DEK-CAN融合基因表达分析[J].中国实验血液学杂志,2006,14(2):232-236. 被引量:8
  • 2Potikyan G,France KA,Carlson MR,et al.Genetically defined EWS1/FLI1 modle system suggests mesenchymal origin of Ewing's family tumors.Lab Invest,2008,88(12):1291-1302.
  • 3Harewood L,Schütz F,Boyle S,et al.The effect of translocationinduced nuclear reorganization on gene expression.Genome Res,2010,20 (5):554-564.
  • 4Cohen AJ,Li FP,Berg S,et al.Hereditary renal-cell carcinoma associated with a chromosomal translocation.N Engl J Med,1979,301 (11):592-595.
  • 5Rosenblum-Vos LS,Meltzer SJ,Leana-Cox J,et al.Cytogenetic studies of primary cultures of esophageal squamous cell carcinoma.Cancer Genet Cytogenet,1993,70 (2):127-131.
  • 6Eberhardt NL,Grebe SK,Mclver B,et al.The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer.Mol Cell Endocrinol,2010,321 (1):50-56.
  • 7Tomlins SA,Rhodes DR,Perner S,et al.Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.Science,2005,310(5748):644-648.
  • 8Cui X,De Vivo I,Slany R,et al.Association of SET domain and myotubularin-related proteins modulates gowth control.Nat Genet,1998,18(4):303-305.
  • 9Fernandez V,Hartmann E,Ott G,et al.Pathogenesis of mantlecell lymphoma:all oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways.J Clin Oncol,2005,23(26):6364-6369.
  • 10Maes B,Vanhentenrijk V,Wlodarska I,et al.The NPM-ALK and the ATIC-ALK fusion genes can be detected in non-neoplastic cells.Am J Pathol,2001,158(6):2185-2193.

二级参考文献15

  • 1龚辉,刘文励,周剑峰,徐慧珍.急性白血病患者骨髓细胞CHFR基因表达及其临床意义[J].中华医学杂志,2005,85(16):1085-1088. 被引量:2
  • 2Shapira MY,Hirshberg B,Amir G,et al.6 ;9 translocation in myelodysplastic syndrome.Cancer Genet Cytogenet,1999; 112:57 -59.
  • 3Boer J,Mahmoud H,Raimondi S,et al.Loss of the DEK-CAN fusion transcript in a child with t(6;9) acute myeloid leukemia following chemotherapy and allogeneic bone marrow transplantation.Leukemia,1997; 11:299 -300.
  • 4Potter MN,Cross NC,van-Dongen JJ,et al.Molecular evidence of minimal residual disease after treatment for leukaemia and lymphoma:an updated meeting report and review.Leukemia,1993;7:1302-1314.
  • 5Yokota H,Kitamura K.The genetic diagnosis of hematopoietic malignancy by polymerase chain reaction method.Rinsho Byori,2000; 48:708 -715.
  • 6Garcon L,Libura M,Delabesse E,et al.DEK-CAN molecular monitoring of myeloid malignancies could aid therapeutic stratification.Leukemia,2005; 19:1338-1344.
  • 7Makita M,Azuma T,Hamaguchi H,et al.Leukemia-associated fusion proteins,dek-can and bcr-abl,represent immunogenic HLADR-restricted epitopes recognized by fusion peptide-specific CD4 +T lymphocytes.Leukemia,2002; 16:2400-2407.
  • 8von-Lindem M,van-Baal S,Wiegant J,et al.Can,a putative oncogene associated with myeloid leukemogenesis,may be activated by fusion of its 3' half to different genes:characterization of the set gene.Mol Cell Biol,1992; 12:3346-3355.
  • 9Shearer BM,Knudson RA,Flynn HC,et al.Development of a DFISH method to detect DEK/CAN fusion resulting from t (6;9)(p23 ;q34) in patients with acute myelogenous leukemia.Leukemia,2005; 19:126-131.
  • 10Tobal K,Frost L,Liu Yin JA.Quantification of DEK-CAN fusion transcript by real-time reverse transcription polymerase reaction in patients with t (6;9) acute myeloid leukemia.Haematologica,2004; 89:1267-1269.

共引文献7

同被引文献2

引证文献1

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部