摘要
天然苷类化合物结构测定过程中核磁共振是测定苷键构型的重要方法。利用端基质子的偶合常数和端基碳的化学位移值判断苷键构型是最常用的方法,但有些糖不适用这种方法,而需要借助13C NMR谱数据分析确定苷键构型。本文通过归纳文献数据,总结利用1H NMR和13C NMR谱的特征判断各种常见单糖苷键构型的方法。
In the structural determination of natural glycosides,nuclear magnetic resonance（NMR） is an important approach in determining the configuration of glycoside bond.The test of coupling constant of the anomeric proton and chemical shift of the anomeric carbon are two common methods,but these methods are not suitable for some sugars.For those sugars,detailed 13C NMR analysis is an alternative choice.This paper summarizes the characteristics of 1H and 13C NMR data of the common monosaccharides published in the literatures,in order to search an approach to determine the configuration of glycoside bond.
出处
《药学学报》
CAS
CSCD
北大核心
2011年第2期127-131,共5页
Acta Pharmaceutica Sinica
关键词
核磁共振
糖苷键
构型
nuclear magnetic resonance
glycoside bond
configuration
