电压门控钾通道在低氧肺动脉高压中的作用
摘要
低氧性肺血管收缩和重建是机体一种重要的代偿反应,但持续的肺血管收缩和重建可引起肺动脉高压,导致肺源性心脏病。K＋通道在血管平滑肌中是重要的效应蛋白并且具有多重功能,如在维持血管张力，控制细胞膜静息电位及调控细胞内的Ca^2＋信号以调节血管的收缩。
出处
《医学研究杂志》
2011年第1期24-26,共3页
Journal of Medical Research
基金
浙江省自然科学基金资助项目(Z2080988)
参考文献17
-
1Haruko I,Taisuke J,Kuniaki I,et al.Molecular and pharmacological characteristics of transient voltage-dependent K+ currents in cultured human pulmonary arterial smooth muscle cells.Br J Pharmacol,2005,146(1):49-59.
-
2Stephen BL,Xiao Tao,Ernest B C,et al.Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.Nature,2007,450:376-382.
-
3Wang J,Letitia W,Wang W,et al.Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery.Am J Physiol Lung Cell Mol Physiol,2005,288:1049-1058.
-
4Eun AK,Won Sun Park,Amy LF,et al.Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells:Modulation by protein kinases.Progress in Biophysics and Molecular Biology,2009,103(1):95-101.
-
5Smirnov SV,Beck R,Tammaro P,et al.Electrophysiologically distinct smooth muscle cell subtypes in rat conduit and resistance pulmonary arteries.J,Physiol,2002,538:867-878.
-
6Standen NB,Quayle JM.K+ channel modulation in arterial smooth muscle.Acta Physiol,Scand,1998,164:549-557.
-
7Eun A K,Jin H,In DJ,et al.Physiological roles of K+ channels in vascular smooth muscle cells.J Smooth Muscle Res,2008,44 (2):65-81.
-
8Hayabuchi Y,Standen NB,Davies NW.Angiotensin II inhibits and alters kinetics of voltage-gated K+ channels of rat arterial smooth muscle.Am J Physiol,2001,281:H2480-H2489.
-
9Cogolludo A,Moreno L,Bosca L,et al.Thromboxane A2-induced inhibition of voltage-gated K+ channels and pulmonary vasoconstriction:role of protein kinase C zeta.Circ Res,2003,93:656-663.
-
10Cogolludo A,Moreno L,Lodi F,et al.Serotonin inhibits voltage-gated K+ currents in pulmonaryartery smooth muscle cells:role of 5-HT2A receptors,caveolin-1,and Kv1.5 channel internalization.Circ Res,2006,98:931-938.
-
1刘小红,刘晓飞,曾秋棠.缬沙坦对大鼠心肌梗死后电压门控钾通道9.X表达变化的影响[J].临床心血管病杂志,2005,21(8):485-487.
-
2徐军,侯恕,陈顺存,钟南山,迟学栋,张荪曦.内皮素在低氧肺动脉高压形成中的作用[J].中华结核和呼吸杂志,1995,18(5):290-292. 被引量：8
-
3黄子旭,沈捷.钙通道在肺动脉高压发病机制中的研究进展[J].临床儿科杂志,2016,34(11):861-865. 被引量：6
-
4柳济成,杨利.低氧性肺动脉高压的中药治疗[J].齐齐哈尔医学院学报,2009,30(9):1096-1098. 被引量：1
-
5高玉慧,朱福音.初步观察高血压病患者血浆脑钠肽水平变化[J].中外医疗,2008,27(10):33-33.
-
6董爱萍,姚锐.心脏机械牵张激活的信号转导途径研究进展[J].咸宁学院学报（医学版）,2008,22(3):274-276.
-
7龙云,唐红.肝纤维化发生机制的研究进展[J].肝脏,2006,11(3):203-205. 被引量：5
-
8张永昶,倪望,甄国华,张珍祥,徐永健.蛋白激酶C对慢性缺氧大鼠肺动脉平滑肌细胞电压门控钾通道的作用[J].中华结核和呼吸杂志,2003,26(6):379-380. 被引量：2
-
9薛耀明,周琳.胰淀素对大鼠胰岛素分泌的影响及胰岛细胞内Ca^(2+)信号调节机制[J].第二军医大学学报,2003,24(5):572-572.
-
10杨艳娟,程德云.低氧大鼠肺内结缔组织生长因子表达与肺血管重建的关系[J].华西医学,2007,22(2):318-320. 被引量：2
