成人与儿童髓母细胞瘤临床特点的分析

Clinical analysis of different characteristics for medulloblastoma in adults and children

目的探讨成人与儿童髓母细胞瘤的临床特点及预后。方法回顾性分析109例经手术和病理证实的髓母细胞瘤病例,分为成人组和儿童组,对其进行综合治疗并随访。结果成人组和儿童组术后平均生存时间分别为69.6个月、32.3个月,术后3年生存率分别为80.8%(21/26)、42.2%(35/83),术后5年生存率分别为69.2%(18/26)、25.3%(21/83)。结论成人与儿童髓母细胞瘤的好发部位、发生机制以及术后放、化疗耐受程度不同,成人髓母细胞瘤的预后普遍好于儿童髓母细胞瘤。

Objective To discuss the clinical features and prognosis of medulloblastoma （ MB ） in adults and children. Methods A total of 109 patients of medulloblastoma confirmed by operations and pathology were studied retrospectivly. They were divided into adult and children, treated and follow-up. Results Adult＇s mean survival time is 69.6 months, after 3-year survival rates is 80.8% （21/26） , 5-year survival rate after surgery is 69.2% （ 18/26 ） ; Children＇s mean survival time is 32.3 months, after 3-year survival rates is 42.2% （35/83）, 5-year survival rate after surgery is 25.3% （21/83）. Conclusions The location, patho- genesis and tolerance of postoperative radiotherapy and chemotherapy between adults and children are differrent, so prognosis of adult medulloblastoma is better than children.