摘要
体细胞诱导重编程为诱导多能干细胞是近年来干细胞研究领域一项新的技术,不仅为体细胞重编程去分化机制的研究注入了新的活力,而且为疾病发生发展相关机制研究及再生医学带来了新的曙光.诱导多能干细胞（iPS细胞）诱导体系作为该技术的核心部分,在转录因子的组成和导入方式、诱导效率及诱导安全性的提高等方面都有不断的进展.就近几年iPS细胞诱导体系的现状与应用前景进行综述和展望.
Induced pluripotent stem（iPS）-cell technology is a great breakthrough in stem cell research field in recent years, it is not only injecting new vitality for the research of reprogramming of somatic cell, but also bringing a new dawn to the study of mechanism of disease and development of regenerative medicine. As key issues of iPS-cell technology, the study of iPS cell induction system has progressed in the composition of transcription factor, gene delivery, as well as induction efficiency. In this article, research advance of iPS cell induction system in recent years is reviewed and the prospect is discussed as well.
出处
《国际生物医学工程杂志》
CAS
北大核心
2010年第6期372-375,共4页
International Journal of Biomedical Engineering
基金
国家自然科学基金资助项目（30971213）
重庆市卫生局重点项目（20090113）
关键词
体细胞重编程
IPS细胞
iPS诱导体系
转录因子
小分子化合物
Somatic cells reprogramming
Induced pluripotent stem cells
iPS inductive system
Transcription factor
small molecules
