胃癌中C-erbB-2、Ki-67的表达及其意义

Expression and significance of C-erbB-2 and Ki-67 in gastric carcinoma

目的:研究C-erbB-2和Ki-67在胃癌中表达和意义。方法:采用免疫组化SP法检测77例原发性胃癌中C-erbB-2及Ki67的表达。结果:C-erbB-2在胃癌中的阳性率为62.3%,在胃炎中的阳性率为6.7%,两者有显著差异(P<0.05)。C-erbB-2在胃癌中的表达与胃癌的浸润深度有关(P<0.05),与胃癌患者的年龄、性别、胃癌的分化程度和淋巴结转移无关(P>0.05)。Ki-67在胃癌中的阳性率为77.9%,在慢性胃炎阳性率为10.0%,两者有显著差异(P<0.05)。Ki-67的表达与胃癌患者的年龄、性别、肿瘤的浸润深度、分化程度和淋巴结转移无关(P>0.05)。结论:C-erbB-2、Ki-67的异常表达和胃癌的早期发生有关。

Objective：To study the expression and significance of C-erbB-2 and Ki67 in gastric carcinoma.Methods：The expression of C-erbB-2 and Ki67 were examined by SP immunohistochemical technique in 77 cases of primary gastric carcinoma samples.Results：The positive rates of C-erbB-2 in gastric carcinoma and gastritis cases were 62.3% and 6.7%,respectively,a significance existed between the two groups（P 0.05）.The expression rate of C-erbB-2 in gastric carcinoma was positively correlated with the invasion depth in gastric carcinoma （P 0.05）,and was not correlated with age,gender,differentiation and lymph node metastasis（P 0.05）.The positive rate of Ki67 in gastric carcinoma and gastritis cases were 77.9% and 10.0%,respectively,a significance was found between the two groups（P 0.05）.The positive rate of Ki67 in gastric carcinoma was not correlated with age,gender,invasion depth,differentiation and lymph node metastasis （P 0.05）.Conclusion：The over-expression of C-erbB-2 and Ki-67 may be involved in early stage of gastric carcinoma.