老年原发性高血压颈动脉粥样硬化与血尿酸相关性分析

Correlation analysis of essential hypertension in elderly carotid atherosclerosis and serum uric acid

目的探讨老年原发性高血压(EH)患者颈动脉粥样硬化(CAS)与血尿酸的相关性。方法选取我院老年原发性高血压患者61例应用高频多普勒超声检测颈动脉内膜-中层厚度(IMT)及斑块情况,并同时抽取空腹静脉血测定血尿酸(SUA)、尿素(BUN)、肌酐(Scr)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)等生化指标。根据颈动脉粥样硬化的程度分为颈动脉IMT正常组(IMT≤0.9mm)、颈动脉IMT增厚组(IMT1.0～1.3mm)及颈动脉斑块形成(IMT≥1.3mm)3组,采取统计学方法分析生化指标与老年高血压患者颈动脉粥样硬化的关系。结果老年原发性高血压(EH)颈动脉内膜-中层厚(IMT)3组间血尿酸比较差异有统计学意义(P<0.05)。结论老年高血压患者随着血尿酸水平增高,颈动脉内膜中层厚度相应增加,提示尿酸可能参与颈动脉粥样硬化的病变的发展,血尿酸与老年高血压患者颈动脉粥样硬化具有相关性,故对高血压患者常规定期检测颈动脉IMT及血尿酸,可以及早发现动脉粥样硬化(AS),预防心脑血管危险因素,早期积极降压达标,控制高尿酸血症,可以延缓老年高血压患者发生AS,保护心脑肾等重要器官,从而减少急性心脑血管事件发生。

Objective To discuss correlation analysis of essential hypertension（EH）in elderly carotid atherosclerosis（CAS）and serum uric acid.Methods 61 cases of elderly patients with essential hypertension were selected in our hospital and examined by high-frequency Doppler on a carotid intima-media thickness（IMT）and plaque situation.Meanwhile fasting venous blood were sampled to determine serum uric acid（SUA）,urea（BUN）,creatinine（Scr）,triglyceride（TG）,total cholesterol（TC）,low-density lipoprotein cholesterol（LDL-C）,fasting blood glucose（FBG）and other biochemical indicators.In accordance with carotid atherosclerosis extent they were divided into normal carotid artery group（IMT≤0.9mm）,carotid artery thickening group（IMT1.0~1.3mm）and the formation of carotid artery plaque group（IMT≥1.3mm）.Statistical methods were taken to analyse the relationship between the biological and chemical indicators and elderly hypertensive patients with carotid atherosclerosis.Result There is statistical significance of difference between senile patients with essential hypertension（EH）of a carotid intima-media thickness（IMT）and serum uric acid among the 3 groups（P0.05）.Conclusion Elderly patients with hypertension increased with the level of serum uric acid and carotid artery intima-media thickness increased correspondingly.This shows that uric acid may be involved in the development of carotid atherosclerosis disease,and serum uric acid and elderly hypertensive patients with carotid atherosclerosis are relevant.So periodic testing of convention tocarotid artery in patients with high blood pressure and serum uric acid can detect atherosclerosis（AS）early and prevent cardiovascular and cerebrovascular risk factors.Early positive step-down standards and control of hyperuricemia can delay occurrence of AS to elderly patients with hypertension,which protects vital organs such as hearts,heads,kidneys and so on,so as to reduce the acute cardiovascular and cerebrovascular events.