牛磺胆酸对小鼠免疫功能的影响

Studies on Immunological Effects of Taurocholate Acid in Mice

目的:研究牛磺胆酸对小鼠免疫功能的影响。方法:采用迟发型皮肤变态反应法测定高、低剂量牛磺胆酸对用7%的二硝基氯苯所致的小鼠迟发型皮肤超敏反应的作用,采用血清溶血素测定法测定高、低剂量牛磺胆酸对绵羊红细胞所致的小鼠溶血素抗体生成的影响,采用碳廓清法测定高、低剂量牛磺胆酸对小鼠单核巨噬细胞吞噬功能的影响。结果:牛磺胆酸能显著抑制小鼠单核巨噬细胞的吞噬功能,对小鼠迟发型皮肤超敏反应有显著的抑制作用,能增强小鼠溶血素含量。结论:牛磺胆酸对小鼠非特异性免疫及细胞免疫具有显著抑制作用,而对体液免疫具有增强作用,对动物的免疫功能具有多方面调节作用。

Objective ： To study the effects of TCA on immune function in mice. Method ： The effects of high and low dose of TCA on delayed skin hypersensitivity mice induced by 7 % DNCB, the production of antibody to hemolysin induced by sheep blood cells in mice, and the function of monocyte macrophage were determined by delayed - type skin allergic reaction, serum hemolysin assay, and carbon clearance, respectively. Results： In mice, TCA could significantly inhibit the function of monocyte macrophage and delayed skin hypersensitivity, while increase the content of hemolysin. Conclusion： TCA can significantly inhibit nonspecific immunity and cellular immunity, but enhance humoral immunity, so it has various regulatory effects on immune function in animal.