阿魏酰哌啶类化合物的合成及其清除羟自由基活性研究

Synthesis and Scavenging Hydroxyl Radical Activity of Feruloyl Piperidine Compounds

目的:合成2个阿魏酰哌啶类化合物,并对其体外清除羟自由基(.OH)活性进行研究。方法:以阿魏酸及其类似物为原料,经乙酰化保护酚羟基、与哌啶酰化、脱乙酰保护基,制得阿魏酰哌啶类化合物;用邻二氮菲-Fe2+氧化法测定目标化合物清除·OH的活性。结果:在试验条件下,所合成的2个阿魏酰哌啶类化合物具有较强的清除·OH的能力。结论:2个阿魏酰哌啶类化合物清除·OH的能力接近于抗坏血酸(Vc),值得进一步深入研究。

Objective： To synthesize two feruloyl piperidine compounds,and to exploit the ability of the compounds to sca-venge hydroxyl radical（·OH）.Methods：Ferulic acid and its analog were acetylated to protect phenolic hydroxyl,then reacted with piperidine,and removed the acetyl to synthesize feruloyl piperidine compounds.The ability of the target compounds to scavenge ·OH was measured by ferrosin-Fe2＋ oxidation method.Results：Under the experimental condition,two feruloyl piperidine compounds showed strong activity to scavenge ·OH.Conclusion：The ·OH scavenging activity of the two compounds is as efficient as Vitamin C,and deserves further research.