免疫激活:关于toll样受体与nod样受体的探索

Activating Immunity:Lessons from the TLRs and NLRs

toll样受体和nod受体在天然免疫应答中是重要的家族。激发配体促进受体相互作用的精确检测从而导致多重信号的形成和多级信号转导的触发。这个过程能导致促炎因子的上调、细胞凋亡和调控其他免疫防御。最近,在这些受体家族中识别激活配体和配体的分子基础的检测上有重大进展。理解这些过程,对于新的疫苗佐剂的开发、感染性疾病的治疗、炎症反应和潜在的疾病甚至癌症,都提供了必要的信息。

The Toll-like receptors and NOD-like receptors are key families in the innate immune response.The specific detection of activating ligand facilitates receptor interactions,the formation of multiprotein signalling complexes and initiation of signal transduction cascades.This process can trigger the upregulation of proinflammatory mediators,apoptosis,and modulation of other immune defences.Recently,significant advances have been made in the identification of new activating ligands and the determination of the molecular basis of ligand recognition within these receptor families.Understanding these processes provides information essential to the development of new vaccine adjuvants and the treatment of infectious diseases,inflammatory disorders and,potentially,cancer.