金龙胶囊联合GP方案对晚期非小细胞肺癌患者血清血管内皮生长因子表达和疗效的影响

The Effects of Jinlong Capsule Combined with GP Regimen on the Expression of Vascular Endothelial Growth Factor in Serum and the Curative Effect on the Patients with Advanced Non-Small Cell Lung Cancer

目的探讨金龙胶囊联合GP方案化疗对晚期非小细胞肺癌(NSCLC)患者血清血管内皮生长因子(VEGF)表达、疗效和症状改善的影响。方法将60例晚期NSCLC随机分为两组:治疗组30例,GP方案化疗+口服金龙胶囊;对照组30例,单纯GP方案化疗。观察治疗前后两组症状改善情况、实体瘤变化、血清VEGF表达水平变化。结果治疗组症状总改善率为80.00%、临床获益率为86.67%、血清VEGF表达水平为(114.66±20.93)ng/L,与对照组症状总改善率53.33%、临床获益率63.33%、血清VEGF表达水平(149.53±27.30)ng/L比较,差异均有统计学意义(P<0.05)。结论金龙胶囊联合GP方案化疗能进一步降低晚期NSCLC患者血清VEGF表达水平,从而提高临床获益率,改善中医症状。

Objective To research the effects of jinlong capsule combined with GP regimen on the expression level of vascular endothelial growth factor（VEGF） in serum,curative effect and improvement of symptom of the patients with advanced non-small cell lung cancer（NSCLC）.Methods Sixty patients with advanced NSCLC were divided into two groups randomly.Thirty cases in the treatment group were treated with GP regimen and jinlong capsule,while 30 cases in the control group were treated with GP regimen merely.The status of symptom improvement,changes of tumor and VEGF level in serum were observed.Results The overall improvement rate in the treatment group was 80.00%,the clinical benefit rate was 86.67%,the VEGF level in serum was（114.66±0.93） ng/L,while the overall improvement rate in the control group was 53.33%,the clinical benefit rate was 63.33%,the VEGF level in serum was（149.53±7.30） ng/L.The difference between the two groups was statistically significant（P0.05）.Conclusion For the patients with advanced NSCLC,jinlong capsule combined with GP regimen can further decrease the VEGF level in serum,improve the clinical benefit rate and ameliorate the clinical symptoms.