不良妊娠结局的环境危险因素影响强度及交互作用研究

THE IMPACT OF ENVIRONMENTAL RISK FACTORS ON ADVERSE PREGNANCY AND THE INTERACTION BETWEEN THEM

目的探讨引起不良妊娠结局的主要环境危险因素,分析这些危险因素之间的影响强度及交互作用。方法采用回顾性调查法,将确诊为不良妊娠结局的120份病例和同期妊娠正常的80份病例进行对照。结果孕妇既往不良妊娠史即流产史对不良妊娠结局的影响强度最大(OR=28.65),并且随着流产次数的增加其危险性增加;吸烟及饮酒是导致不良妊娠结局的重要因素,包括配偶吸烟(OR=6.24)、孕前被动吸烟(OR=5.15)、孕期被动吸烟(OR=2.81)、配偶饮酒(OR=3.07);夫妻双方不良环境接触史及孕期患病也会影响妊娠结局(OR值分别为3.23、3.22、1.83)。结论避免多次流产,戒除吸烟、饮酒等不良嗜好,减少与宠物、农药、甲醛及电磁辐射等的接触,孕期增强身体免疫力,对降低不良妊娠结局有重要作用。

Objective To investigate the impact of environmental risk factors on adverse pregnancy,and to analyze the interaction between them.Methods 120 cases of adverse pregnancy and 80 cases of normal pregnancy received retrospective epidemiological surveys.Results Previous abortions contributed most to spontaneous abortion（OR=28.65）,and the more the previous abortions occurred,the greater the risk became.Smoking and drinking are important risk factors,including spouse smoking（OR=6.24）,pre-pregnancy passive smoking（OR=5.15）,pregnancy passive smoking in pregnancy period（OR=2.81）and spouse drinking（OR is 3.07）.The previous exposure to adverse environmental risk factors and illness during pregnancy also affected normal pregnancy（OR=3.23,3.22 and 1.83）.Conclusion To avoid multiple abortions,to quit smoking and drinking,to avoid contact with pets,pesticide,formaldehyde and electromagnetic radiation,and to strengthen immunity all play important roles in reducing adverse pregnancy outcomes.