白藜芦醇乳脂体的制备和工艺考察

Preparation and process study of resveratrol emulsomes

目的:采用薄膜分散法制备白藜芦醇乳脂体,并对其进行处方及工艺优化。方法:以包封率为指标进行正交设计优化处方工艺。结果:制备白黎芦醇乳脂体最佳处方为:磷脂与三硬脂酸甘油酯比例30∶1,磷脂与胆固醇比例10∶1,药物与磷脂比例1∶25,磷脂与吐温-80比例5∶1。最佳工艺为:水合时间90 min,水合温度35℃,水浴温度45℃,超声时间12 min。结论:该处方工艺可行,所制备的白藜芦醇乳脂体具有较高包封率。

Objective： To prepare resveratrol emulsome with thin film sonication method and to optimize its process.Methods： The entrapment efficiency of formulation and process factors were investigated,and the orthogonal optimization formulation was designed.Results： The better prescription for the preparation of resveratrol emulsome was the ratio of phospholipids and three stearic acid glyceride was 30∶1;the ratio of phospholipid and cholesterol was 10∶1;the ratio of phospholipids and drug was 25∶1;the ratio of phospholipids and the ratio of Tween-80 was 5∶1;the better process was as follows： the hydration time： 90 min;hydration temperature： 35 ℃;water temperature：45 ℃;ultrasonic time： 12 min.Conclusion： The formulation technology is feasible,and the encapsulation efficiency of resveratrol emulsomes is high.