盐酸米诺环素软膏治疗舰船官兵慢性牙周炎的疗效观察

Therapeutic effects of minocycline hydrochloride on chronic periodontitis in navy vessel personnel

目的观察盐酸米诺环素软膏治疗舰船官兵慢性牙周炎的疗效。方法将海军某部官兵体检中检出的符合慢性牙周炎纳入标准的60例患者,取左右同位置牙周炎患牙共120颗进行自身对照实验,左右侧患牙随机纳入实验组和对照组,进行常规牙周洁治与龈下刮治、牙周袋冲洗后,实验组牙周袋置放盐酸米诺环素软膏,对照组置放20 g/L碘甘油。治疗前、治疗后第5周和第7周,分别检查和记录菌斑指数(PLI)、牙周袋深度(PD)、牙龈指数(G I)和探诊出血指数(SB I)。结果治疗后第5周、第7周,2组患牙临床指标均较基线有明显改善(P<0.01),实验组优于对照组(P<0.01)。结论盐酸米诺环素软膏治疗慢性牙周炎疗效显著,使用方便,对舰船官兵牙周炎患者较为适用。

Objective To observe the therapeutic effects of minocycline hydrochloride on chronic periodontitis in navy vessel personnel. Methods Chronic periodontitis personnel in certain navy unit was found 60 cases in health examination. 120 bad teeth of 60 cases lay at the site of latent symmetry which were randomly divided into test group （60 teeth） and control group （60 teeth）. The test group was treated by minocycline bydrochloride and the control group was treated by iodoglycerin after the teeth in the two groups were made clean, gingival scaling, periodontal pocket wash. The periodontal pocket depth （PD）, the gingival index （GI）, the plaque index （PLI） and the sulcus bleeding index （SBI） were recorded before treatment and on the 5th and the 7th weeks after treatment. Results Compared with the baseline, all the clinical indexes of the two groups were improved obviously on the 5th and the 7th weeks after treatment and the indexes in the test group were better than those in the control group. The differences were statistically significant. Conclusion Local drug delivery of minocycline hydrochloride is an effect and convenient method for treatment of chronic periodonfitis in navy vessel personnel.