阿魏酸钠注射液治疗瘀血阻络型肝硬化腹水40例疗效观察

Treatment of cirrhosis ascites with obstruction of collaterals by blood stasis by sodium ferulate injection

目的观察阿魏酸钠注射液治疗瘀血阻络型肝硬化腹水的临床疗效。方法将78例瘀血阻络型肝硬化腹水患者随机分为2组,治疗组40例予阿魏酸钠注射液200 mg,每日1次静脉滴注;对照组38例予丹参注射液20 mL,每日1次静脉滴注。2组均30 d为1个疗程,2个疗程后评定疗效,随访12个月后观察远期效果。结果治疗组总有效率92.5%,对照组总有效率68.4%2,组总有效率比较差异有统计学意义(P<0.05);治疗组治疗后肝功能及B超情况较治疗前均有明显改善(P<0.05),对照组治疗后血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBiL)及门静脉主干内径较本组治疗前均有明显改善(P<0.05);治疗组治疗后AST、白蛋白(Alb)、门静脉主干内径及脾厚改善情况均优于对照组(P<0.05);治疗组治疗后纳差、腹胀、倦怠乏力、寐欠、便秘、便溏、小便少、黄疸、双下肢水肿改善率优于对照组(P<0.05)。结论阿魏酸钠注射液治疗瘀血阻络型肝硬化腹水疗效确切。

Objective To observe the clinical effect of cirrhosis ascites with obstruction of collaterals by blood stasis by sodium ferulate.Methods 78 patients of cirrhosis ascites with obstruction of collaterals by blood stasis were randomly divided into two groups.40 cases in treatment group were treated by intravenous drip of sodium ferulate injection.38 patients in control group were treated by intravenous drip of Danshen injection.The course was 30 days in two groups.The effect was evaluated after two courses.The long-term effect was observed follow-up of 12 months later.Results The total effective rate in treatment group（92.5%） was superior to that in control group（68.4%,P0.05）.Hepatic function and type-B ultrasonic after treatment were significantly improved in treatment group（P0.05）.ALT,AST,TBiL and inner diameter（ID） of main portal vein（MPV） after treatment were significantly improved in control group（P0.05）.The improvement of AST,Alb,ID of MPV and Thickness of spleen in treatment group was superior to that in control group after treatment（P0.05）.The improvement of symptoms of traditional Chinese medicine including poor appetite,abdominal distension,Languid and constipation etc in treatment were superior to those in control group after treatment（P0.05）.Conclusion Sodium ferulate injection has definite effect on cirrhosis ascites with obstruction of collaterals by blood stasis.