术前生化指标与分化型甲状腺癌术后首次131I内照射疗效的关系

Relationship between preoperative biochemical indexes and effect of postoperative first 131I internal irradiation for differentiated thyroid carcinoma

目的 分析131I内照射术前各项生化指标与分化型甲状腺癌术后首次131I内照射疗效的关系.方法 对180例分化型甲状腺癌术后首次131I内照射治疗的患者按内照射疗效分为有效组（96例）和无效组（84例）,对其临床资料进行回顾性分析.结果 有效组和无效组患者内照射术前血清碱性磷酸酶（AKP）和促甲状腺激素（TSH）分别为（74.83±19.77）、（65.50±11.84）U/L和（3.12±0.59）、（2.57±0.56）mU/L,差异有统计学意义（t=3.77、6.39,P〈0.01）.结论 术前血清AKP和TSH水平是影响分化型甲状腺癌术后首次131I内照射疗效的重要因素.

Objective To analyze the relationship between preoperative biochemical indexes and effect ofpostoperative first 131I internal irradiation for differentiated thyroid carcinoma. Methods One hundred and eighty patients of thyroid carcinoma within the first 131I internal irradiation postoperative. According to curative effect were divided into effective group （96 cases） and invalid group （84 cases） and their clinical data were retrospectively analyzed. Results The preoperative serum alkaline phosphatase （AKP） and thyroid-stimulating hormone （TSH） in effective group and invalid group were respectively （74.83 ± 19.77）,（65.50 ± 11.84） U/L and （3.12 ±0.59）, （2.57 ±0.56） mU/L. There were significant difference （t =3.77,6.39, P 〈 0.01） between two groups. Conclusion The levels of preoperative serum A KP and TSH are important factors to influence the effect of postoperative first 131I internal irradiation for differentiated thyroid carcinoma.