阿尔茨海默病患者血清TGF-β_1的测定

Analysis of TGF-β_1 in serum of patients with Alzheimer's disease

目的:探讨阿尔茨海默病中转化生长因子β1(TGF-β1)测定在诊治中的临床价值。方法:酶联免疫吸附分析法(ELISA)测定66例阿尔茨海默病患者和143例正常人血清TGF-β1含量,两者加以比较。结果:阿尔茨海默病组TGF-β1含量明显低于正常组,两组间存在显著性差异(P<0.05)。结论:TGF-β1参与阿尔茨海默病的发生。

Objective：T o study the effects of transforming growth factor-β1（TGF-β1） in Alzheimer’ s Disease（AD）.Methods：There were 66 AD patients whose serum concentration of TGF-β1 was tested and compared with that of 143 normal persons.Results：The serum concentration of TGF-β1 in the AD patients（73.45±52.64） ng/ml was lower than the normal persons’（94.62ng/ ml ± 43.74ngΠ ml）（P〈0.05） 1There was significant differences between the two groups.Conclusions： TGF-β1 is possibly concerned with the occurrence and progress of Alzheimer’s disease.