非糖尿病患者尿微量白蛋白与冠状动脉病变相关性分析

The relationship of microalbuminuria and coronary artery disease in non-diabetes mellitus patients

目的:探讨非糖尿病患者尿微量白蛋白与冠状动脉病变程度的相关性。方法:将266例行选择性冠状动脉造影(CAG)的患者分为四组:1组为冠状动脉正常组;2组为单支病变组;3组为双支病变组;4组为三支病变组(含左主干病变)。所有患者均进行尿微量白蛋白(UMA)测定,同时收集患者年龄、性别、吸烟、病史、家族史等相关资料,评价UMA对冠状动脉病变程度的预测价值。结果:①冠状动脉粥样硬化性心脏病(CAD)组尿微量白蛋白异常者的比率明显高于冠状动脉正常组(P<0.05);②UMA水平与冠脉病变程度呈正相关,单支病变与双支病变、三支病变两两比较,UMA水平有显著差异(P<0.05)。结论:随尿微量白蛋白增高,冠状动脉病变程度加重,UMA>30 mg/L是预测患者冠状动脉病变程度的早期指标,是冠心病的强有力预测因子。

Objective：To evaluate the value of microalbuminuria（UMA） in predicting the extent of coronary artery lesions according to coronary angiography（CAG） in patients without diabetes mellitus.Methods：We studied 266 consecutive patients without diabetes mellitus who had taken coronary angiography or percutaneous coronary intervention.All patients underwent UMA examination.All subjects were divided into four groups according the result of the CAG.The CAG result was normal for the first group;the second group was single vessel lesion;the third group was double vessel lesions and the fourth group was three vessels which including left main lesion.The applicability of UMA is the markers for predicting coronary heart disease（CHD）.Results： Compared with the coronary artery normal group,the value of UMA is higher than that of the coronary artery abnormal group（P〈0.05）.The level of UMA was correlated with the severity of coronary lesions.There were significant differences between single vessel disease and two or more vessel lesions（P〈0.05）.Conclusions： With the increasing of UMA,there is more vessels lesion.UMA〉30mg/L is early factor in predicting the extent of coronary artery lesions.