依那普利联合拜阿司匹林治疗早期糖尿病肾病临床观察

Treatment of diabetic nephropathy with enapril and aspirin

目的观察依那普利联合拜阿司匹林对早期糖尿病肾病(DN)以及不同程度血浆粘度增高的治疗效果。方法将48例24小时尿微量白蛋白排泄量在30-300mg的2型糖尿病(DM)患者随机分为A、B两组,各24例,在常规降糖治疗的同时,A组单用依那普利治疗,B组为依那普利联合拜阿司匹林治疗,治疗12周后,分别观察治疗前后两组24小时尿微量白蛋白、血浆粘度、收缩压、舒张压、血肌酐的变化。结果两组治疗后,24小时尿微量白蛋白、血浆粘度、收缩压、舒张压较治疗前下降(P<0.05),血肌酐较治疗前无明显改变(P>0.05),但B组24小时尿微量白蛋白、血浆粘度下降明显大于A组(P<0.05)。结论依那普利联合拜阿司匹林治疗早期糖尿病肾病,可降低尿蛋白排泄延缓肾小球硬化,对保护肾脏功能具有重要的临床意义。

Objective To observe the effect of enapril and aspirin on early diabetic nephropathy（DN）.Methods 48 type 2 diabetes mellitus（DM） patients with 24 hours microalbuminuria excretion in 30-300mg were randomly divided into A and B group.A group was treated with stilamin enapril treatment.B group were treated with enapril and aspirin.The 24 hours microalbuminuria and plasma viscosity,systolic blood pressure and diastolic blood pressure,creatinine changes were observed.Results The 24 hour microalbuminuria,plasma viscosity,systolic blood pressure and were decreased after treatment（P0.05）.The 24 hours microalbuminuria and plasma viscosity of B group were lower than that of A group（P0.05）.Conclusion It is effective for early diabetic nephropathy treated with enapril and aspirin.