摘要
目的探讨血清B型脑钠肽(B-type natriuretic peptide,BNP)和净脱水量在急性肾衰竭患者持续性肾脏替代治疗(continous renal replacement therapy,CRRT)中的变化。方法选择5例于四川大学华西医院行CRRT治疗超过24h的少尿型急性肾衰竭患者,采用ELISA方法测定0、4、8、12和24h的血清及超滤液BNP水平,运用Person分析对血清BNP降低值和净脱水量进行相关性分析。结果血清BNP呈时间依赖性下降(P<0.05);随着净脱水量增加,血清BNP的下降相应增加(r=0.798,P<0.01);超滤液BNP水平极低,且差异无统计学意义(P>0.05)。结论少尿型急性肾衰竭患者进行CRRT治疗后的容量负荷有所减轻,血清BNP显著下降;血清BNP的下降与净脱水量成正相关;BNP可从滤液中滤出,但浓度极低。
Obstructive The purpose of the study is to investigate the relationship between the serum B-type natriuretic peptide（BNP） level and the net amount of dehydration in patients with acute renal failure who were undergoing CRRT.Methods 5 patients with oliguric acute renal failure were included in the study.All patients were undergoing CRRT longer than 24 hours.The serum BNP and ultrafiltration fluid in patients at the time of 0,4,8,12 and 24h during the CRRT were measured with ELISA.The correlation between the decreased level of serum BNP and ultrafiltration volumes was analyzed with Person＇s linear correlation analysis.Results The serum BNP level was decreased gradually during the CRRT.The level of serum BNP at 24h significantly decreased compared with that at 0h（P0.05）.The decreased level of serum BNP was dramatically correlated to the ultrafiltration volume（r=0.698,P0.01）.Conclusion After CRRT,the volume load of patients with oliguric acute renal failure decreased to a certain extent and the level of serum BNP were decreased dramatically.The decreased level of serum BNP had the positive correlation with the increased ultrafiltration volume.
出处
《西部医学》
2011年第2期268-270,共3页
Medical Journal of West China
