系统性红斑狼疮感染状况及死亡原因分析

Infection of patients died from systemic lupus erythematosus

目的研究SLE死亡患者相关的感染状况,分析SLE合并的感染引起死亡的危险因素,为临床工作中正确预防并控制感染,提高患者的生存率,提供一定的参考。方法采用回顾性调查分析方法,搜集2005年1月-2010年2月在四川大学华西医院及绵阳市中心医院风湿免疫科住院的SLE死亡患者,分析死亡SLE患者的直接死因、该组病例感染情况、病原学情况,并将该组患者分为死于感染者和死于非感染组,分析感染导致死亡的危险因素。结果 686例患者中死亡52例,占7.58%,感染是死亡的最主要原因（27例,占51.92%）,其中肺部感染最常见,占21例。感染的病原菌以G-菌为主。肺部感染、合并狼疮性肾炎与感染导致的死亡有相关性。结论感染是SLE患者死亡的最主要原因,肺部感染、合并狼疮性肾炎与感染导致的死亡有相关性。

Objective To investigate the infection condition of patients died from systemic lupus erythematosus（SLE）.Methods The clinical and laboratory data of dead patients with SLE were analyzed.Results Of 52 patients（7.58%） died of 686 SLE patients,there were 27（51.92%）died from infection.Infection was the major cause of death.Statistical analysis showed that pulmonary infection and complicated with lupus nephritis were relevant to the death from infection.Conclusion Infection is the major cause of death in SLE patients,pulmonary infection and complicated with lupus nephritis are relevant to the death from infection.