妊娠期高血压患者血清瘦素、TNF-α和胰岛素变化的分析

Analysis of the change of serum leptin,tumor necrosis factor-α and insulin in patients with gestational period hypertension

目的:探讨血清瘦素、肿瘤坏死因子-α(TNF-α)、胰岛素与妊娠期高血压疾病(HDCP)的关系。方法:采用放射免疫法测定48例HDCP患者(HDCP组)和20例正常晚期妊娠妇女(对照组)的血清瘦素、TNF-α和胰岛素水平,分析瘦素与TNF-α、胰岛素的相关性。结果:HDCP组血清瘦素、TNF–α、胰岛素水平显著高于对照组(P<0.01),HDCP组血清瘦素与TNF-α、瘦素与胰岛素之间均呈显著正相关。结论:HDCP患者血清瘦素、TNF-α、胰岛素水平均明显升高,血清瘦素、TNF-α和胰岛素水平的变化与妊娠期高血压疾病密切相关。

Objective： To explore the relations of serum leptin,tumor necrosis factor-α（TNF-α） and insulin levels in hypertensive disorder complicating pregnancy（HDCP）.Methods： Radioimmunoassay was used to test the levels of fasting serum leptin,TNF-α and insulin in 48 patients with HDCP（HDCP group） and 20 normal pregnant women（control group）.The correlation of leptin and TNF-α,insulin were explored.Results： Levels of leptin,TNF-α and insulin of HDCP group were significantly higher than those of normal pregnant women（P0.01）.Leptin level of HDCP group was positively correlated to TNF-α,insulin level.Conclusion： Serum leptin,TNF-α and insulin level obviously increases in pregnant women with HDCP,and they are closely correlated with the disease.