乳杆菌活菌胶囊配合制霉菌素治疗外阴阴道假丝酵母菌病的临床研究

Clinical observation on Living Preparation of Lactobacillus combined with Nystatin in the treatment of vulvovaginal candidiasis

目的:探讨乳杆菌活菌胶囊(商品名:定君生)配合制霉菌素治疗外阴阴道假丝酵母菌病(VVC)的疗效。方法:把120例VVC患者随机分为治疗组(60例)和对照组(60例)。治疗组先给予制霉菌素(50万U/片)治疗,阴道上药,1片/次,1次/d,连续用药10 d,接着给予定君生1粒,阴道上药,1次/d,连续5 d;第2、3个月月经干净后继续给予制霉菌素、定君生,阴道上药,方法和剂量同前。对照组仅用制霉菌素(50万U/片)1片,阴道上药,1次/d,连续10 d;第2、3个月月经干净后继续给予制霉菌素,阴道上药,方法和剂量同前。两组治疗3个疗程后观察其疗效。结果:治疗组总有效率为96.7%,对照组总有效率为73.3%,治疗组疗效优于对照组,两组比较差异有统计学意义(P<0.05)。结论:定君生配合制霉菌素治疗外阴阴道假丝酵母菌病疗效明显。

Objective： To investigate the efficacy of Living Preparation of Lactobacillus combined with Nystatin in the treatment of vulvovaginal candidiasis（VVC）.Methods： 120 patients with VVC were randomly divided into two groups,treatment group and control group,with 60 cases in each group.Treatment group was given Nystatin（500 000 U/tablet）,one tablet,once a day,going up through vagina on medicine,for 10 days,and then given Living Preparation of Lactobacillus,one tablet,going up through vagina on medicine,once a day,for 5 days.Using the same ways after menstrual in the next two months.Control group was given Nystatin（500 000 U/tablet）,one tablet,going up through vagina on medicine,once a day,for 10 days,using the same ways after menstrual in the next two months.The efficacy of two groups were evaluated after 3 courses of treatment.Results： The total effective rate was 96.7% in the control group,while 73.3% in the treatment group.Comparison of the effective in the two groups,the treatment group had a better efficacy than the control group,there was significant difference between two groups（P0.05）.Conclusion： Living Preparation of Lactobacillus combined with Nystatin in the treatment of VVC has a remarkable efficacy.