厄多司坦祛痰作用的疗效观察

Expectorant effect of erdosteine

目的观察国产厄多司坦祛痰作用的疗效。方法 78例患者随机分为治疗组(n=40)和对照组(n=38),治疗组口服国产厄多司坦胶囊300 mg,一日2次;对照组口服溴已新片16 mg,一日3次。疗程均为7天。结果治疗组和对照组的临床总有效率分别为67.5%和57.9%,两组对比差异无统计学意义(P>0.05);祛痰有效率分别为85.0%和63.1%,两组比较有显著性差异(P<0.05);不良反应发生率分别为5%和7.9%,两组对比无显著性差异(P>0.05)。结论国产厄多司坦胶囊用于祛痰治疗疗效和安全性与溴已新相当。

Objective To observe the expectorant effect of erdosteine made in China. Methods Seventy-eight patients were randomly divided into treatment group （n=40）and control group （n=38）.The patients in treatment group were administrated with erdosteine capsules 300 mg orally twice a day, and the patients in control group were administrated with bromhexine hydrochloride tablets 16 mg orally three times a day for 7 days. Results The total effective rates of rates of treatment and control group were 67.5% and 57.9%, and there was no significant difference between two groups （P 〉0.05）. The effective rates of expectorant of treatment and control group were 85.0% and 63.1% respectively, and there was significant difference between two groups （P〈0.05）. The rates of adverse reaction were 5% and 7.9% respectively, and there was no significant difference between two groups （P〉0.05）. Conclusion China made erdosteine capsule is as safe and effective as bromhexine hydrochloride for expectoration.