罗库溴铵对不同丙泊酚镇静水平脑电双频指数和脑状态指数的影响

Effect of rocuronium on bispectral index and cerebral state index under different sedation levels induced by propofol

目的观察罗库溴铵对丙泊酚不同镇静水平脑电双频指数(BIS)和脑状态指数(CSI)的影响。方法选择ASAⅠ或Ⅱ级气管插管全麻行择期手术患者70例,分为罗库溴铵组(L1、L2组,n=20)和生理盐水组(C1、C2组,n=15),L1、C1组效应室浓度(Ce)设定为2.5μg/ml,L2、C2组Ce设定为4.0μg/ml。比较麻醉诱导前(T0)、气管插管前(T1)、气管插管即刻(T2)、气管插管后3min(T3)、5min(T4)、注射罗库溴铵/生理盐水前(T5)、注射罗库溴铵/生理盐水后最大作用强度时(T6)及肌颤搐恢复时(T7)的HR、MAP,并记录T5～T7时的BIS、CSI。结果 L1组BIS、CSIT6时较T5、T7时下降(P<0.05)。结论丙泊酚Ce为2.5μg/ml时,罗库溴铵会导致BIS、CSI下降。

Objective To investigate the effects of rocuronium on the bispectral index（BIS）and cerebral state index（CSI）in patients under different sedation levels induced by propofol.Methods Seventy ASA Ⅰ or Ⅱ patients undergoing general anesthesia were randomized into two groups according to the propofol＇s effect concentration（Ce）,which were subsequently divided into 4 subgroups：two groups with rocuronium（group L1 and L2,n=20）and two groups with NS（group C1 and C2,n=15）.In group L1 and C1 the Ce of propofol was set to 2.5 μg/ml,and 4.0 μg/ml for group L2 and C2.SBP,DBP,MAP,HR,BIS and CSI were recorded before induction of anesthesia（T0）,before tracheal intubation（T1）,at the moment of the intubation（T2）,3 min（T3）,5 min（T4）after intubation,the time before rocuronium/NS administration（T5）,the time of most efficiency of rocuronium（T6）and the recovery of twitch responds of muscle（T7）.Results In group L1,BIS and CSI were greatly decreased at T6 when compared with those at T5 and T7（P〈0.05）.Conclusion Rocuronium decreased BIS and CSI in patients who received propofol with the Ce of 2.5 μg/ml.