急性冠状动脉事件患者ICAM-1的变化及其临床意义分析

Circulating ICAM-1 in patients with acute coronary disease can help to predict cerebral vascular events

目的评价急性冠状动脉事件患者血管细胞间黏附分子1(ICAM-1)浓度及与脑缺血危险性的关系及临床意义。方法对沈阳军区总医院2009年1月至2010年03月入院急性冠脉综合征患者134例,双抗体夹心酶联免疫吸附法测定ICAM-1,并随访患者180 d内出现脑血管疾病的情况。结果轻度狭窄组、中度狭窄组、重度狭窄组3组间ICAM-1表达差异有统计学意义。中度狭窄组和重度狭窄组ICAM-1浓度显著增高,与对照组和轻度狭窄组比较差异有统计学意义。重度狭窄组中有36%出现TIA,与ICAM-1浓度随着血管狭窄的程度加重而增加的现象一致。而在冠状动脉左前降支发生狭窄超过50%的所有患者中,脑血管疾患的发生率也明显增加。结论 ICAM-1浓度和急性冠脉综合征患者冠脉狭窄程度及主要心血管不良事件率相关,监测ICAM-1浓度变化具有重要临床意义。

Objective To evaluate the risk of cerebral ischemia by vascular ICAM-1 concentration in patients with acute coronary syndrome. Methods A total of 134 patients with acute coronary syndrome,who were treated from January 2009 to December 2009, were included in the present study. Double antibody sandwich enzyme- linked immunosorbent assay was used for determination of ICAM-I. The cerebral vascular events were followed up for 180 days. Results There is a significant different ICAM-1 between stenosis≤50% two groups and stenosis 〉 50% two groups and also the cerebral ischemia risk evaluated in the group difference was statistically significant levels of ICAM-1 is the stenosis 〉 50% two groups. Conclusion ICAM concentration is associated with the acute coronary syndrome and coronary artery stenosis rate ; monitoring the concentration of vascular endothelial growth factor has important clinical significance.