哌甲酯对注意缺陷多动障碍患儿事件相关电位的影响

Effects of Methylphenidate on Event Related Potential in Children with Attention Deficit Hyperactivity Disorder

目的比较哌甲酯对注意缺陷多动障碍(ADHD)患儿治疗前后事件相关电位的影响。方法 ADHD患儿32例口服哌甲酯后应用丹迪Keypoint肌电-诱发电位仪进行Go/Nogo任务的事件相关电位检测,以30名健康儿童作为健康对照组,对事件相关电位主成分进行比较。应用SPSS 13.0软件进行统计学分析。结果 ADHD患儿服药后Go-P3潜伏期(355.16±17.04)ms,短于服药前(366.66±19.32)ms,但长于健康对照组(333.70±23.57)ms(Pa<0.05);波幅(5.88±1.72)μV,高于服药前(4.82±2.14)μV,但低于健康对照组(7.19±1.87)μV(Pa<0.05);ADHD患儿服药后Nogo-P3波幅(6.13±1.68)μV,高于服药前(5.04±1.76)μV,但低于健康对照组(8.32±2.03)μV(P<0.05,0.01)。结论哌甲酯能改善ADHD患儿的注意性及抑制性执行功能。

Objective To investigate the effect of methylphenidate on event related potential（ERP） in children with attention deficit hyperactivity disorder（ADHD）.Methods Thirty-two children with ADHD（ADHD group）were treated for oral using methylphenidate and observed for 2 hours,scale for the assessment of methylphenidate were evaluated with the P300 ERP in Go/Nogo task.Thirty healthy children（healthy control group） were controls,to compare the differences of ERP main components.Results The latency[（355.16±17.04） ms] and amplitude[（5.88±1.72） μV] of Go-P3 in ADHD group after treatment were significantly shorter and higher than before treatment[（366.66±19.32） ms and（4.82±2.14） μV,Pa0.05],but longer and lower than those in healthy control group[（333.70±23.57） ms and（7.19±1.87） μV,Pa0.05].The amplitude [（6.13±1.68） μV] of Nogo-P3 in ADHD group after treatment were significantly higher than before treatment[（5.04±1.76） μV,P0.05],but lower than that in healthy control group[（8.32±2.03） μV,P0.05].Conclusion Methylphenidate can improve the attention and inhibitive executive functions in children with ADHD.