鼻咽癌64排CT表现与bcl-2蛋白表达关系的研究

Study of 64-CT with bcl-2 Protein Expression in Nasopharyngeal Carcinoma

目的研究bcl-2蛋白表达与鼻咽癌64排CT表现的关系。方法经活检病理证实的鼻咽癌30例,均行64排螺旋CT扫描,收集CT征象,采用免疫组织化学方法检测bcl-2蛋白表达情况,并分析CT征象与其bcl-2蛋白表达的相应关系。结果 bcl-2蛋白阳性表达率在鼻咽癌单侧壁肿块组与多侧壁肿块组分别为72.22%与83.33%,差异无显著性意义(P>0.05);在咽旁脂肪间隙消失组与无咽旁脂肪间隙消失组分别为100%与11.11%,差异有显著性意义(P<0.05);侵及后鼻道组与无侵及后鼻道组分别为93.75%与64.27%,差异有显著性意义(P<0.05);侵及上颌窦组与无侵及上颌窦组分别为89.47%与54.54%,差异有显著性意义(P<0.05)。在颅底骨质破坏组与无颅底骨质破坏组,bcl-2蛋白阳性表达率分别为100%与37.5%,差异有显著性意义,(P<0.05),颈部淋巴结转移组与无颈部淋巴结转移组分别为80%与75%,差异无显著性意义(P>0.05)。结论 bcl-2蛋白在鼻咽癌的发生、发展中起重要作用,其阳性表达与鼻咽癌的浸润深度有一定的相关性,因此bcl-2蛋白表达率可作为评价鼻咽癌CT表现恶性程度的指标。

Objective To study the relationship between the expression of bcl-2 and 64-CT findings of nasopharyngeal carcinoma（NPC）.Methods 30 patients of NPC were confirmed by biopsy with 64-CT scanning,then the relationship between the expressions ofbcl-2 and CT features was analyzed.Results The positive expression rates of bcl-2 were 72.22% and 83.33% in the single lateral wall and the multiple lateral wall of nasopharynx（P0.05） respectively.The positive expression rates of bcl-2 were 100.00% and 11.11% in para pharyngeal space narrowing respectively（P0.05）.It were 93.75% and 64.27% in posterior naris involved and without（P0.05）.It were 89.47% and 54.54% in lower pharyngeal involved and without（P0.05）.It were 100.00% and 37.50% in bone destruction of skull base and without（P0.05）.It were 80.00% and 78.57% in lymph node metastasis in neck and without（P0.05）.Conclusion Bcl-2 might play an important role in development of nasopharyngeal carcinoma.Bcl-2 protein expression was correlated with invasive depth and prognosis metastasis.Bcl-2 could be served as indicator for predicting prognosis and malignancy of CT findings of nasopharyngeal carcinoma.