清肾胶囊延缓慢性肾功能衰竭进程的实验研究

Experimental Study of Qingshen Capsule on Delaying the Progress of Chronic Renal Failure

采用５／６肾切除大鼠造成慢性肾功能衰竭（ＣＲＦ）模型，观察清肾胶囊对Ｓｃｒ水平，ＴＧ、ＣＨＯ、ＨＤＬ－ＣＨＯ、Ｆｉｂ水平，免疫组化分析肾组织Ⅳ型胶原水平，计算机图像分析测定各组肾小球直径、细胞数、肾小球细胞基质（ＥＣＭ）面积的影响。清肾胶囊能延缓ＣＲＦ大鼠肾功能的衰竭，其作用优于开博通：在对残余肾结构的保护方面与开搏通相似，能抑制肾小球肥大，减轻肾小球ＥＣＭ的堆积，减少Ⅳ型胶原的合成。对ＣＲＦ大鼠功能和结构产生良好的影响。

To study the effect of Qingshen capsule on the renal function of the 5/6 nephrectomized rats and its protective effect on the structure of the remnant kidney.After treated for 12 weeks,the rats were sacrificed.The serum ceratinine(Scr) was measured and the renal lesions and the collagen deposition in the sclerosis glomerulus were investigated.Results:The Scr of Qingshen capsule groups is lower than that of the other two groups.Qingshen capsule and Cap can inhibit the glomerular hypertrophy,decreased ECM and abate collagen deposition in the glomerulus.Conclusion:Qingshen capsule not only can delay the progress of chronic renal failure,but also play a protective role on renal remnant kidney.