粪便隐血单克隆抗体法在检测结、直肠癌中的临床应用

Clinical study on monoclonal antibody dectection of faecal occult blood in colorectal cancer

目的评价粪便隐血单克隆抗体法对检测结、直肠癌的意义。方法对７８例确诊为结、直肠癌病人用单克隆抗体法和联苯胺法检测粪便隐血。结果单克隆抗体法和联苯胺法的阳性率分别为８４．６％、６１．５％（Ｐ＜０．０１）。结论单克隆抗体法检测结、直肠癌敏感性远远超过传统联苯胺法。为了提高对结直肠癌的早期诊断率，我们建议常规采用单克隆抗体法进行粪便隐血检测。

Objective To evaluate the simplication of monoclonal antibody dectection of faecal occult blood(FOB)in colorectal cancer. Method To dectect FOB in 78 colorectal cancer with monoclonal antibody and benzidine methods. Result Postive rate of monoclonal antibody and benzidine methods in 78 colorectal cnnaacer was 846% and 615% respectively(P<001). Conclusion Monoclonal antibody method of FOB showed higher sensitivity than benzidine method in colorectal cancer.We suggest to apply monoclonal antibody method of FOB instead of tranditional method to dectect early colorectal cancer.