摘要
背景丙泊酚是目前临床常用的静脉麻醉药，其具有起效快、作用时问短及安全性高的特点。但是30％-70％患者会出现注射疼痛的副作用，对患者机体和精神造成了严重影响。目的为减轻丙泊酚临床给药疼痛提供有效的解决策略，为新制剂研发提供思路。内容对近年来国内外学者关于丙泊酚注射疼痛机理的研究进展进行分析评述，概括导致丙泊酚注射疼痛的各种假设机制。趋向为解决临床注射给药导致疼痛这一共性问题提供新思路。
Background Propofol was commonly used as intravenous anesthetics, which has a rapid onset, short duration of action and high security. But 30% to 70% of patients have side effect of pain on injection, which impact on the psychosomatic health of patient seriously. Objective To provide effective clinical therapeutic strategy for alleviating the pain of propofol administration, and provide new ideas for developing new propofol agents. Content We summarized various hypothesis and mechanisms of inducing pain on propofol injection by analyzing and reviewing the investigation and progression about the mechanism of pain on propofol injection at home and abroad. Trend From these reviews, we want to provide some suggestion and reference for treatment of pain on propofol injection
出处
《国际麻醉学与复苏杂志》
CAS
2011年第1期109-112,共4页
International Journal of Anesthesiology and Resuscitation
基金
基金项目：陕西省重大科技创新项目（2006ZKC04）
