心型脂肪酸结合蛋白在心肌损伤诊断中的研究进展

The research progress on the diagnosis of myocardial injury of heart-type fatty acid-binding protein

背景心肌标志物的正确应用为临床准确诊断、鉴别心血管疾病和判断治疗效果起到了革命性的作用，目前已经有越来越多的心肌损伤标志物在临床中得到应用，现对心型脂肪酸结合蛋白（heart-type fatty acid-binding protein，H-FABP）的研究相关进展作一综述。目的了解H-FABP的理化性质和临床检测方法，认识H-FABP在早期心肌梗塞诊断中的独特优势。内容结合国内外文献对H-FABP的基础和临床研究现状进行了阐述，对目前临床检测的方法进行了介绍，并对发展的趋势做了进一步展望。趋向随着H-FABP测定方法的不断改进及临床研究的不断深入，H-FABP正逐渐成为诊断心肌损伤的重要生化标志物。

Background The correct application of cardiac markers have played a revolutionary role for clinical accurate diagnosis, identification and treatment of cardiovascular disease. Now more and more cardiac biochemical markers have been applied in clinic researches, and the latest research progress in the field of H-FABP is reviewed in this paper. Objective To understand the physical and chemical properties and clinical detection methods of H-FABP, to recognize the unique advantages in diagnosis of the early AMI. Content To survey the basic and clinical research of H-FABP by reviewing domestic and international literatures, and to introduce the current clinical detection methods. Trend With the development of H-FABP determination methods and clinical research, H-FABP is becoming an important biochemical marker of myocardial injury.